Distribution of Systemic Ciprofloxacin and Doxycycline to Gingiva and Gingival Crevicular Fluid

Gingival Crevicular Fluid Biomarkers

Material and Method: Thirty patients were allocated into 3 groups: 10 were treated with scaling and root planing (SRP) only; 10 were treated with SRP and received adjunctive local metronidazole; 10 were treated with SRP and received adjunctive systemic metronidazole. Periodontal clinical parameters including plaque index, sulcus bleeding index, probing depth and relative attachment level were r...

Subantimicrobial-dose doxycycline modulates gingival crevicular fluid biomarkers of periodontitis in postmenopausal osteopenic women.

BACKGROUND We recently demonstrated that a 2-year subantimicrobial-dose doxycycline (SDD) regimen (double-masked, placebo-controlled clinical trial) in postmenopausal (PM) women exhibiting mild systemic bone loss (osteopenia) and local bone loss (periodontitis) reduced the progression of periodontal attachment loss (intent-to-treat analysis) and the severity of gingival inflammation and alveola...

Determination of Ciprofloxacin in Human Gingival Crevicular Fluid by High-performance Liquid Chromatography

A simple and selective high-performance liquid chromatographic (HPLC) method has been developed for determination of ciprofloxacin in human gingival crevicular fluid (GCF). GCF samples were collected with paper strips. Ciprofloxacin was extracted from the pooled strips with methanol–water, 50:50 (v/v), and separated on a cartridge column (Radial-pak C18, 100 mm × 8 mm, 10 μm) with acetonitrile–...

Hydroxyproline titers in gingival crevicular fluid.

Cytokines in gingival crevicular fluid of adolescents and young adults.

BACKGROUND/AIM The purpose of this study was to compare the levels of the cytokines interleukin-1beta (IL-1beta), IL-4, and IL-8 in the gingival crevicular fluid (GCF) of adolescents and young adults. METHODS Twenty-five adolescents aged between 14 and 16 years (Group A) and 20 periodontally healthy young adults aged between 25 and 35 years (Group B) were selected from two private dental clin...